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Your Space - How to Become an Early Riser - Part II
Last Monday’s post How to Become an Early Riser obviously struck a chord with many people. That post has generated more links than I can count, sending more new traffic to this site than any other post or article I’ve written. And the traffic logs indicate that the surge was decentralized (not attributable to a mention in any one major source).
You can get an idea of what that post did for Ste
You can get an idea of what that post did for Ste
According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
vePavlina.com’s traffic at Alexa (note the big spike at the end of May 2005). Alexa isn’t very accurate, but it’s good enough for noting general trends.
Last Monday I did a Google search on “how to become an early riser” (in quotes). It returned zero results. Now look at how many results it returns.
OK, so this was an instalanche. But why? Getting up early is a relatively benign topic, isn’t
Last Monday I did a Google search on “how to become an early riser” (in quotes). It returned zero results. Now look at how many results it returns.
OK, so this was an instalanche. But why? Getting up early is a relatively benign topic, isn’t
; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.
Examples of combination products may in
Examples of combination products may in
t? At least I thought it was at the time I posted it.
Since this appears to be a topic of interest, even though I don’t fully understand why, I figured I’d do a follow up post to add some more detail.
First, on the subject of going to bed when you’re sleepy… to do this correctly requires a mixture of awareness and common sense.
If you’re doing stimulating activities before bed, you’ll be abl
Since this appears to be a topic of interest, even though I don’t fully understand why, I figured I’d do a follow up post to add some more detail.
First, on the subject of going to bed when you’re sleepy… to do this correctly requires a mixture of awareness and common sense.
If you’re doing stimulating activities before bed, you’ll be abl
lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.
to stay up later and stave off sleepiness for a while. In college I used to participate in poker games that went until dawn, and then we’d often go out to breakfast afterwards. I can easily stay up later than my normal range of bed times if I work, go out with friends, or do other stimulating activities.
But this isn’t what I meant by noticing when you’re sleepy. I mentioned the test of not b
But this isn’t what I meant by noticing when you’re sleepy. I mentioned the test of not b
here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
ing able to read more than a couple pages of text without losing concentration. This doesn’t mean waiting until you’re about to drop from exhaustion.
The onset of sleepiness I’m referring to is when your brain starts releasing hormones to knock you out. This is different from just being tired. You actually feel yourself getting drowsy. But in order for this to happen, you need to create the ri
The onset of sleepiness I’m referring to is when your brain starts releasing hormones to knock you out. This is different from just being tired. You actually feel yourself getting drowsy. But in order for this to happen, you need to create the ri
d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.
Combination pro
Combination pro
ght conditions for it to occur. This means giving yourself some downtime before bedtime. I find that reading is a great way to wind down before bed. Some people say reading in bed is a bad idea… that you should only sleep in bed. I’ve never had a problem with it though, since when I’m too sleepy to keep reading, I can just put the book down and go to sleep. But read in a chair if you prefer.
A
A
ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
other test you can use is this. Ask yourself, “If I were to go to bed now, how quickly could I fall asleep?” If you think it would take more than 15 minutes to fall asleep, I say go ahead and stay up.
Once you set a fixed awakening time, it may take a bit of practice to hone in on the right range of bedtimes for you. In the beginning you may see some huge oscillations, staying awake too late o
Once you set a fixed awakening time, it may take a bit of practice to hone in on the right range of bedtimes for you. In the beginning you may see some huge oscillations, staying awake too late o
easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
e night and going to bed too early another night. But eventually you’ll get a feel for when you can go to bed and fall asleep right away while allowing yourself to wake up refreshed the next day.
As a failsafe to keep yourself from staying up too late, give yourself a bedtime deadline, and even if you aren’t totally sleepy, go to bed by that time no matter what. I have a good idea of the minim
As a failsafe to keep yourself from staying up too late, give yourself a bedtime deadline, and even if you aren’t totally sleepy, go to bed by that time no matter what. I have a good idea of the minim
nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
m amount of sleep I need. 6.5 hours per night is sustainable for me, but I can do 5 hours in a pinch and be OK as long as I don’t do it every night. The maximum I ever sleep is 7.5 hours. Before I started waking up at a fixed time each morning, I’d often sleep 8-9 hours, sometimes even 10 hours if I was really tired.
If you consume caffeine during the day, it’s likely to mess with your sleep c
If you consume caffeine during the day, it’s likely to mess with your sleep c
and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
ycles. So the original post assumes you aren’t drugging yourself to stay awake. If you’re addicted to caffeine, then break the addiction first. Don’t expect natural sleepiness to occur at the right time if you’re screwing with your brain chemistry.
The idea of the original post was to explain how to develop the habit of arising early. So the advice is geared towards creating the habit. Once th
The idea of the original post was to explain how to develop the habit of arising early. So the advice is geared towards creating the habit. Once th
ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
habit is established, it runs more subconsciously. You can be doing stimulating activities like work or playing video games, and you’ll just know when it’s time for you to go to bed, even though it may be a different time each night. The sleepiness test is important for developing the habit, but subtler signals will take over afterwards.
You can always sleep in late now and then if you need t
You can always sleep in late now and then if you need t
ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.
Following aspects would a
Following aspects would a
. If I stay up until 3am, I’m not going to get up at 5am the next morning. But I’ll return to my usual routine the next day.
I recommend getting up at the same time for 30 days straight to lock in the habit, but after that you’ll be so conditioned to waking up at the same time that it will be hard to sleep in. I decided to sleep in late one Saturday morning and didn’t set my alarm, but I woke
I recommend getting up at the same time for 30 days straight to lock in the habit, but after that you’ll be so conditioned to waking up at the same time that it will be hard to sleep in. I decided to sleep in late one Saturday morning and didn’t set my alarm, but I woke
dd to the challenges in developing combination products:
Which markets to tap where the combination products can do fairly well?
Which combination prod
Which markets to tap where the combination products can do fairly well?
Which combination prod
p automatically at 4:58 am. Then I tried to sleep in, but I was wide awake and couldn’t fall back asleep again. Oh well. Once the habit is established, it isn’t hard at all to get up, assuming you’re going to bed at the onset of sleepiness.
If you have kids, adapt as needed. My kids are ages 5 and 1. Sometimes they wake me up in the middle of the night — my daughter is in the habit of doing th
If you have kids, adapt as needed. My kids are ages 5 and 1. Sometimes they wake me up in the middle of the night — my daughter is in the habit of doing th
cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
is lately, popping into the bedroom to tell my wife and me about her dreams or sometimes just to chat. And I know what it’s like when there’s a baby waking up every few hours. So if you’re in that situation, I say that the rule is to sleep when you can. Babies aren’t very good at sticking to schedules. :)
If you can’t get yourself out of bed when your alarm goes off, this is likely due to a la
If you can’t get yourself out of bed when your alarm goes off, this is likely due to a la
tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
k of self-discipline. If you have enough self-discipline, you’ll get out of bed no matter what. Motivation can also help, but motivation is short lived and may only last a few days. Discipline is like a muscle. The more you build it, the more you can rely on it. Everyone has some discipline (can you hold your breath?), but not everyone develops it. There are a lot of ways to build discipline —
t?
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
’ve written a whole chapter on this topic in my upcoming book. But basically it comes down to taking on little challenges, conquering them, and gradually progressing to bigger ones. It’s like progressive weight training. As your self-discipline gets stronger, a challenge like getting out of bed at a certain time will eventually become trivially easy. But if your self-discipline has atrophied, i
ping new procedures for reviewing their safety, efficacy and quality.
Professional from academic institutions, pharmaceutical industries, health care indust
Professional from academic institutions, pharmaceutical industries, health care indust
can seem an almost insurmountable hurdle.
Why get up early?
I’d say the main reason is that you’ll have a lot more time to do things that are more interesting than sleeping.
Again, I’ve gained about 10-15 hours per week doing this. That extra time is very noticeable. By 6:30am, I’ve already exercised, showered, had breakfast, and I’m at my desk ready to go to work. I can put in a lot of hou
Why get up early?
I’d say the main reason is that you’ll have a lot more time to do things that are more interesting than sleeping.
Again, I’ve gained about 10-15 hours per week doing this. That extra time is very noticeable. By 6:30am, I’ve already exercised, showered, had breakfast, and I’m at my desk ready to go to work. I can put in a lot of hou
y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
rs each day of productive work, and I’m usually done with work by 5:00 pm (and that includes personal “work” like email, paying bills, picking up daughter from preschool, etc). This gives me 5-6 hours of discretionary time every evening for family, leisure activities, Toastmasters, reading, journaling, etc. And best of all, I still have energy during this time. Having time for everything that’s
.
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
important to me makes me feel very balanced, relaxed, and optimistic.
Think about what you could do with that extra time. Even an extra 30 minutes per day is enough to exercise daily, read a book or two each month, maintain a blog, meditate daily, cook healthy food, learn a musical instrument, etc. A small amount of extra time each day adds up to significant amounts over the course of a year.
Think about what you could do with that extra time. Even an extra 30 minutes per day is enough to exercise daily, read a book or two each month, maintain a blog, meditate daily, cook healthy food, learn a musical instrument, etc. A small amount of extra time each day adds up to significant amounts over the course of a year.
elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.
Companies that provide selfless information through particip
Companies that provide selfless information through particip
0 minutes a day is 182.5 hours in a year. That’s more than a month of working full-time (40 hours per week). Double it if you save 60 minutes a day, and triple it if you save 90 minutes a day. For me the savings was about 90 minutes/day. That’s like getting a free bonus year every decade. I’m using this time to do things that I previously didn’t have the time and energy to do. It’s wonderful. :
tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products
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