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Your Space - Death by Cigarettes
It has long been known that smoking and lung cancer are causally linked. After having discovered this association though, much has been made of the heightened incidence of other forms of cancer caused by of smoking. I am going to high
According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
light the data that reiterates the claims and suggest that the evidence is not so strong for other forms of cancer being causally linked with smoking. The evidence is analysed from the mortality statistics for the UK in 2002.
I will
I will
; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.
Examples of combination products may in
Examples of combination products may in
work through the statistics because 26% of the population are smokers and so one might reasonably assume that any incidence of cancer where less than 26% of sufferers are smokers may have other more prevalent causes than smoking.
Fir
Fir
lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.
stly, we will deal with the cancer deaths so lets get underway with the 33,600 deaths from lung cancer. 84% of these deaths were in smokers. This means that the average 26% of the smoking population yielded more than three times the p
here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
roportion of deaths – a clear link.
Oesophageal cancer deaths numbered just under 5,000 and the deceased were found to be 66% smokers, 71% and 65% men to women respectively; again another clear link that smoking and oesophageal cance
Oesophageal cancer deaths numbered just under 5,000 and the deceased were found to be 66% smokers, 71% and 65% men to women respectively; again another clear link that smoking and oesophageal cance
d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.
Combination pro
Combination pro
r are linked.
Next, bladder cancer takes over 1,800 lives per year of which 37% are found to be smokers. However, only 19% of female cases were smokers compared with 47% of male cases. It is fair to assume that there are other factor
Next, bladder cancer takes over 1,800 lives per year of which 37% are found to be smokers. However, only 19% of female cases were smokers compared with 47% of male cases. It is fair to assume that there are other factor
ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
s more prevalent in female bladder cancer other than smoking but the link is clear in men.
Stomach cancer took 1,650 lives in 2002 but is found in 35% of men compared with only 11% of female smokers. It is reasonable therefore to dra
Stomach cancer took 1,650 lives in 2002 but is found in 35% of men compared with only 11% of female smokers. It is reasonable therefore to dra
easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
w the same conclusion about the causes as for bladder cancer between men and women.
Pancreatic cancer is another cancer that is less prevalent in smokers than the general population. Indeed 20% of men and 26% of women dying from the
Pancreatic cancer is another cancer that is less prevalent in smokers than the general population. Indeed 20% of men and 26% of women dying from the
nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
disease in 2002 were smokers, suggesting parity with women and a disparity with men. It may be reasonable therefore to assume that there are other contributory factors in male pancreatic cancers.
Death from cancer of the upper respir
Death from cancer of the upper respir
and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
atory tract was found at a rate of 66% in smokers, nearly three times the percentage of smokers. Note though that women sufferers represented half of their cohort compared with three quarters of men, suggesting upper respiratory cance
ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
r is more likely in men than in women smokers.
Kidney cancer is another cancer where smokers are seen less frequently than non-smokers in the statistics.
The next disease we shall look at is the non-cancerous, chronic obstructive pu
Kidney cancer is another cancer where smokers are seen less frequently than non-smokers in the statistics.
The next disease we shall look at is the non-cancerous, chronic obstructive pu
ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.
Following aspects would a
Following aspects would a
lmonary disease or COPD. The disease manifests itself mainly in two forms, being emphysema and chronic bronchitis.
Emphysema is the destruction of the lung leading to loss of surface area, alveoli (air sacks in the lungs) and the los
Emphysema is the destruction of the lung leading to loss of surface area, alveoli (air sacks in the lungs) and the los
dd to the challenges in developing combination products:
Which markets to tap where the combination products can do fairly well?
Which combination prod
Which markets to tap where the combination products can do fairly well?
Which combination prod
s of elasticity. Chronic bronchitis manifests itself through swollen bronchii and over production of mucus within the lung. It is characterised by daily coughing, bringing up sputum. Both emphysema and bronchitis lead to slow, debilit
cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
ating and frustrating deaths for their victims.
Deaths from COPD in 2002 in the UK numbered 28,500 of which 84% were smokers demonstrating a clear link between the inhalation of tobacco smoke and the disease as is the case with lung
Deaths from COPD in 2002 in the UK numbered 28,500 of which 84% were smokers demonstrating a clear link between the inhalation of tobacco smoke and the disease as is the case with lung
tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
cancer.
Some sources suggest that pneumonia is more likely to kill in smokers but only 17% of the 36,000 fatal pneumonia cases were found in smokers suggesting this is not the case.
Finally, heart disease is the biggest single kille
Some sources suggest that pneumonia is more likely to kill in smokers but only 17% of the 36,000 fatal pneumonia cases were found in smokers suggesting this is not the case.
Finally, heart disease is the biggest single kille
t?
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
r in the UK with over a quarter of a million deaths a year as a result of its various forms.
Of all the major forms of heart disease, ischaemic heart disease, cerebrovascular disease, aortic aneurysm, myocardial degeneration and athe
Of all the major forms of heart disease, ischaemic heart disease, cerebrovascular disease, aortic aneurysm, myocardial degeneration and athe
ping new procedures for reviewing their safety, efficacy and quality.
Professional from academic institutions, pharmaceutical industries, health care indust
Professional from academic institutions, pharmaceutical industries, health care indust
rosclerosis, the percentage of smokers suffering from aortic aneuryism was just under 60%. All other forms of heart disease showed near 26% or below. This suggests that smoking may not be the main contributory factor but it almost cer
y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
tainly will have had an impact.
All in all, there were over 114,000 premature deaths in 2002 from cigarette smoking, mostly from cancer, but also from heart disease and pulmonary (lung) disease. The best way to improve ones chances o
All in all, there were over 114,000 premature deaths in 2002 from cigarette smoking, mostly from cancer, but also from heart disease and pulmonary (lung) disease. The best way to improve ones chances o
.
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
f not suffering from a shortened life and succumbing to one of the diseases mentioned in this article is by quitting smoking once and for all. Benefits have been clearly documented and the sooner smokers quit, the bigger the benefits
elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.
Companies that provide selfless information through particip
Companies that provide selfless information through particip
of quitting become on their life expectancy. Indeed, smokers who quit before they reach thirty, statistically negate virtually all the ill health effect of smoking and can generally expect to live as long as a non-smoking contemporary
tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products
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