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Your Space - Clash of the Fats - Triglycerides Verses Essential Fatty Acids
I confess that as a child I used to occasionally watch professional wrestling. For the true fan I suppose it is pronounced rasslin’. Once in a while my kids will find a match on television. I try to explain to them that all the hard work to which they apply themselves during the week to bolster their intelligence can be nearly eradicated in less than on
According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
e hour by watching such theatrics. My ten year old simply responds by saying something in Latin that I don’t understand.
The intrigue, I presume, is that of battle. As boys we hoped that one day we would be like these titans. Not in their goofy shenanigans, but in their sheer power. As men most of us realize that we never were like them. We enjoy the b
The intrigue, I presume, is that of battle. As boys we hoped that one day we would be like these titans. Not in their goofy shenanigans, but in their sheer power. As men most of us realize that we never were like them. We enjoy the b
; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.
Examples of combination products may in
Examples of combination products may in
ttle from the sofa or in our minds. But we do enjoy it. We enjoy the indomitable spirit, the raw strength, the clash. It is part of the human condition. Man against man, champion against champion.
Most of our battles are fought on fronts that are much more mundane. But they are real battles. The problem is some of our most significant conflicts are fou
Most of our battles are fought on fronts that are much more mundane. But they are real battles. The problem is some of our most significant conflicts are fou
lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.
ght on such ordinary fronts that we tend to ignore them. Health issues are like that. As I sit here writing these words I realize I do that. I ignore preventive measures because the tyranny of the urgent captures my attention and occupies my time. After all I have five children with another on the way. I only have time to deal with the most pressing mat
here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
ers. When I get sick I must deal with it. But I find it difficult to take extra measures to prevent the ailments in the first place. If we are talking about a stomach virus or the common cold the issue is not very serious. But what about heart disease? Since the early 20th century heart disease has been climbing. Actually it is an epidemic. Ignoring it
d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.
Combination pro
Combination pro
could be much more serious than catching a cold. Yet I ignore it. Most likely so do you.
For a long time we have known that high total cholesterol, high LDL cholesterol and low HDL cholesterol are bad news for heart health. But more recently it has become increasingly obvious that high triglycerides elevate one’s risk of developing heart disease. We he
For a long time we have known that high total cholesterol, high LDL cholesterol and low HDL cholesterol are bad news for heart health. But more recently it has become increasingly obvious that high triglycerides elevate one’s risk of developing heart disease. We he
ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
r about it on the television and we read about it on cereal boxes. Yet we ignore it. But perhaps by using a little imagination we might have our interest peaked a bit. What if we could tap into the intrigue of the battle in relation to triglycerides?
Triglycerides are fats. That immediately turns many of us off. Parenthetically triglycerides are necess
Triglycerides are fats. That immediately turns many of us off. Parenthetically triglycerides are necess
easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
ary for life and are a good part of our wonderful design. But we are concerned with high triglycerides. These are the bad guys. They wear the black hats. These are represented by the wrestler who wears the ugly hood to conceal his identity. He is vile and unattractive. He spits as he yells his taunts. As he mocks all his opponents the audience mocks him
nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
The only thing attractive about him is the blonde in his corner calling him baby. We know she is an add-on but she is part of the package.
High triglycerides are a nasty business. They have their attractive side, mostly in the sweets and fats that permeate our diets. But don’t be fooled. They are bad news. They are not worth the blonde in the corner.
High triglycerides are a nasty business. They have their attractive side, mostly in the sweets and fats that permeate our diets. But don’t be fooled. They are bad news. They are not worth the blonde in the corner.
and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
What we need to do battle with this villain is someone in a white hat. We need someone who tips his hat to the ladies and who enters the saloon but never drinks whiskey. He is always a gentleman. But he has a deadly aim. Few wrestlers wear hats but we know the good guys when they enter the ring. They have a neat appearance, are polite to everyone and t
ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
e crowd loves them. But in many respects they are like their opponents. They are human. And they are strong. They just happen to be on the opposite side of the conflict. They are on the right side.
In our universe there is a sense of drama. It is interesting to me that one of the greatest opponents to high triglycerides is also a fat. Like two wrestler
In our universe there is a sense of drama. It is interesting to me that one of the greatest opponents to high triglycerides is also a fat. Like two wrestler
ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.
Following aspects would a
Following aspects would a
in the ring or two soldiers on the battlefield, what makes the battle so interesting is that two like things are paired up for the war.
In our battle for heart health two champions on either side of the conflict pair up against each other. It is a strange concept to many in our age of drugs. But if you want to reduce your triglycerides do so with anot
In our battle for heart health two champions on either side of the conflict pair up against each other. It is a strange concept to many in our age of drugs. But if you want to reduce your triglycerides do so with anot
dd to the challenges in developing combination products:
Which markets to tap where the combination products can do fairly well?
Which combination prod
Which markets to tap where the combination products can do fairly well?
Which combination prod
her fat.
There is a whole list of fats that are good for us. They are called essential fatty acids. They are essential in the sense that they are necessary for health. But they are also essential in that our bodies can not make them. We must consume them in our diets. In other words we must eat fat to reduce the effects of fat. If we want to lower our
There is a whole list of fats that are good for us. They are called essential fatty acids. They are essential in the sense that they are necessary for health. But they are also essential in that our bodies can not make them. We must consume them in our diets. In other words we must eat fat to reduce the effects of fat. If we want to lower our
cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
riglycerides one of the most effective things we can do is eat more fat.
Sounds great doesn’t it? Like most things, however, we must be selective. All essential fatty acids are necessary for health. Not all of them, however, should be consumed in unlimited amounts. In relation, though, to reducing triglycerides one essential fatty acid rises to the top
Sounds great doesn’t it? Like most things, however, we must be selective. All essential fatty acids are necessary for health. Not all of them, however, should be consumed in unlimited amounts. In relation, though, to reducing triglycerides one essential fatty acid rises to the top
tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
like a champion. That one is called omega-3. Omega-3 fatty acid has been studied and tested and shown many times to reduce triglycerides. The science is incontrovertible. So much so that even the American Heart Association recommends two to four grams of omega-3 per day for patients with high triglycerides.
Omega-3 is found in many places. Even vegeta
Omega-3 is found in many places. Even vegeta
t?
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
ians have a selection. But for lowering triglycerides the marine sources of omega-3 have been shown to be much more potent than their vegetative cousins. EPA and DHA (the two potent forms of marine omega-3) are found in fish oils from cold water fatty fish like salmon, mackerel and tuna. Cultures that have diets high in fish (marine source omega-3) show
ping new procedures for reviewing their safety, efficacy and quality.
Professional from academic institutions, pharmaceutical industries, health care indust
Professional from academic institutions, pharmaceutical industries, health care indust
a low incidence of heart disease. Their blood platelets are less sticky, their cholesterol levels are healthier and their triglycerides are lower. All this from eating fat.
So what should we do? If we can ignore the potential problems of pollutants like mercury we should eat more fish, especially cold water fish, lots of it. Not only would this replac
So what should we do? If we can ignore the potential problems of pollutants like mercury we should eat more fish, especially cold water fish, lots of it. Not only would this replac
y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
many of the saturated fats in our other dietary choices but it would counteract some of the damage incurred from less healthy fats.
But for many of us eating fish is the exception rather than the rule. We would rather have the blonde in the corner. But in so doing we are getting the villain in the mask. It is all part of the package. Applying a little
But for many of us eating fish is the exception rather than the rule. We would rather have the blonde in the corner. But in so doing we are getting the villain in the mask. It is all part of the package. Applying a little
.
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
discipline in our dietary choices can help a great deal. But even a little discipline may not be enough. Consuming two to four grams of EPA plus DHA per day to reduce triglycerides takes a lot of fish eating. Unless you live in an igloo and take a dogsled to work you may find it difficult to eat enough fish. Fish oil supplements may be your answer. The
elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.
Companies that provide selfless information through particip
Companies that provide selfless information through particip
e are many on the market. Just make sure you buy yours from a trusted source. You want to make sure you are getting what you are paying for (omega-3) and nothing else (mercury).
Heart health does involve a sense of the theatric. In your battle to reduce triglycerides enlist your own titan. In many cases there is no need to send a drug to do a fat’s job
Heart health does involve a sense of the theatric. In your battle to reduce triglycerides enlist your own titan. In many cases there is no need to send a drug to do a fat’s job
tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products
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