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Popular opinion suggests that if you are seriously looking to lose weight, that you should consume six meals a day. Why six? What magic number does six repr

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

esent that you could not get with say, four or five?

Six meals per day lends itself to eating roughly every 3 waking hours. Most people are up for approxi

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

mately 15 hours each day. Eating every three hours would equate to about six meals each day. Go ahead and figure it out. If you are up at 6:30am and tuck i

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

nto bed at 10:30pm, then you will have been awake for 16 hours.

If you eat your first meal at 7am then every three hours from that point on, you will come t

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

six meals at 10pm.

Ok, so you see eating every three hours equates to six meals a day, but why every three hours? Good question! Let's give you some basi

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

c understanding on how the human body works.

Whenever you consume food, your body reacts in a multitude of ways. Your blood sugar elevates, hormones are r

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

eleased, etc. We will focus on your blood sugar as that is a major reason why we want to eat every three hours.

You see, when you eat a balanced meal contai

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ning carbohydrates, proteins and fats, your blood sugar levels elevate. As a result, you then produce a hormone responsible for transporting that blood sug

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

r to muscles and your liver. This hormone is called insulin and is the major player in nutrient transport. Some say it is the most powerful of all hormone

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

s when looking to lose fat and gain lean muscle.

If blood sugar drops and stays low for prolonged periods of time, your body equates this "down time" as a ti

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

me of famine. Because of this "famine" period, your body will try to elevate blood sugar by breaking down muscle tissue to use as fuel. This is not a desire

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

d affect as the loss in muscle tissue results in a lowering of resting metabolism.

A favorable way to keep blood sugar and the hormone insulin under control

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

s through the proper frequency of meals. Meal timing is a very powerful way to raise metabolic processes favorable to those seeking fat loss.

Let's walk th

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

rough an example of meal frequency based on the amount of calories already being consumed.

Let us say we are consuming 1800 calories on a daily basis. Norma

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

lly we eat three times per day. So each meal is roughly 600 calories. Now let us take those same calories and spread them out over six meals per day. We c

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ome up with 300 calories per meal.

We are now consuming the same amount of calories over a wider time frame, so our body is able to manage the processing of

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

hose calories more efficiently. Because we are taking in calories more frequently, but in smaller doses, our body processes these calories faster and becomes

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

accustomed to receiving these frequent "feedings".

Frequent eating programs your body to immediately process those foods and expects the next meal to come

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

soon. This has a prominent effect on your resting metabolic rate (RMR). Simply by increasing frequency, you are able to boost your RMR which has been shown t

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

o be responsible for roughly 60-70% of your daily caloric expenditure.

So remember to plan ahead and get your six meals a day diet into your overall program

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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