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There are many kinds of loose leaf Japanese green teas produced in Japan. If you go to a specialty tea store in Japan, you would be amazed at the range available to samp

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

le. It can be quite daunting for the amateur tea-drinker. Having lived in Japan for 4 years, I have found that sencha and gyokuro green tea are both popular and can be e

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

njoyed by following the tips below.

Sencha Green Tea

The most widely drunk green tea in Japan is sencha green tea. Japanese people drink several cups a day with a meal

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

or between meals. Sencha green tea is made by a process of steaming, drying and rolling of the leaves. The steaming process halts the oxidation of the leaves and mainta

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ins the high level of polyphenols in the tea. This process differentiates it from black tea, where the leaves are left out in the sun to oxidize-turning the leaves from

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

green to brown.

The taste and flavour of loose leaf sencha will vary depending on the grade of sencha. Premium sencha green tea has a mild, slightly sweet flavour. Lowe

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

r grade tea produced from later pickings of the tea bush, will tend to be more astringent than premium grade green tea, produced from the first picking. The brewing of l

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

oose leaf green tea is important as water that is too hot, or over-brewing the tea leaves, will produce more astringent green tea.

When brewing green tea you should all

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ow 1 heaped teaspoon (5g) per 240ml (8oz.) cup of water. You should pour the desired amount of water into the teapot to first heat the teapot. After 30 seconds, pour the

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

water into a tea cup (so you are also warming the tea cup). When brewing loose leaf sencha you should not use freshly boiled water, as this will scorch the tea leaves.

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

y heating the teapot and tea cups you can reduce the temperature to about 70-80 degrees C (165-176 degrees F). Once the water has cooled, add the desired amount of leave

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

s to the teapot, followed by the water. Brew sencha green tea for 2 minutes.

Gyokuro Green Tea

Gyokuro green tea is the highest grade of green tea in Japan. It is usua

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

lly drunk from small tea cups and it is usually sold in smaller quantities than most other green teas. Gyokuro leaves are a rich, dark green because the bushes are cover

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ed with reed screen two or three weeks prior to picking. This protects the leaves from direct sunlight, and helps to produce a subtler and mellow flavour than sencha gre

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

en tea. When sencha leaves are picked, they are steamed and then dried. The leaf stems and veins are removed in the drying process. And unlike other green teas, the leav

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

es are not rolled.

Gyokuro green tea has a mild and delicate flavour. There should be little taste of astringency when drinking gyokuro green tea. When you brew gyokuro

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

you should use 2 heaped teaspoons per 240ml (8oz.) cup of water. Heat the teapot and tea cups as explained above (with sencha green tea), and let the water cool slightl

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

y longer to about 50-60 degrees C(122-140 degrees F). You should steep the tea for 2-3 minutes.

Brewing loose leaf green tea is that simple. Try to use purified water,

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

as using tap water will affect the taste. Also take care not to use water too hot and to over-brew the tea. If you use these tips, you should be able to make a delicious

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

cup of tea. The other great thing about loose leaf green tea, is you can brew the tea 2-3 times. You can leave the tea leaves to steep a little longer with each brewing

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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