Your Space - Health and Fitness

Negative calorie foods are those that need more calories to metabolize than the calories they have. For example, if you eat an apple, which has about 65 calories,

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

your body spends about 100 calories in digestion. That is, the body loses about 35 calories in the process and results in weight loss to that extent. Therefore,

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

he apple you have eaten is a negative calorie food. Normally, when you eat any food, your body burns anywhere between 150 and 250 calories, on an average, for its

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

digestion. So if the food you eat has more than 250 calories, say 350 calories, then your gain in weight is equivalent to 100 calories, which represent the exces

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

calories contained in the food eaten over the calories used up in the digestion of that food. Negative calorie foods result in net loss in terms of calories for

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

the body and, naturally, cause weight loss.

Can I lose weight with negative calorie foods alone?

Based on this theory, negative calorie foods have gained immens

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

popularity as means of losing weight quite effectively. However, considerable controversy surrounds the theory. Negative calorie diets attract criticism because

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

of several factors that go against them. There are people who overeat negative calorie foods under the mistaken notion that they will not gain any weight, but ins

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ead, they can lose their excess weight faster that way. There is another wrong notion that negative calorie diets work for weight loss, without any physical exerc

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ise being included in the weight-loss program. There is no conclusive evidence based on scientific studies that negative calorie foods work the way they are belie

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ed to work. Negative calorie foods are only vegetables and fruits, so it is rather difficult to depend exclusively on them, even if you are a vegetarian.

On the

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ther hand, supporters of negative calorie diets say that they are the only diets that work in fact for weight loss, while the other diets never work. You can alwa

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ys add other foods like fish or lean meat to a negative calorie diet containing fruits and vegetables, and they will not fail.

Starvation diets are, they say, a

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

yth, as starvation or skipping meals will only slow down the metabolism in the body, which holds on to its stored fat in times of food deprivation, but will not r

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

esult in weight loss in the long run. Fat-free and low-fat diets also do not work; speeding up metabolism is the only way for losing weight. There is no end, howe

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

er, to the criticism directed against one diet or the other.

Almost all negative calorie foods contain antioxidants. They are also full of vitamins and minerals.

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

Most of them possess properties beneficial for preventing diseases and promoting good health.

One can list more than a hundred negative calorie foods that reall

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

help you to lose weight. You must incorporate a lot of physical exercise in the negative calorie diets for them to work much better.

Like most others, you may b

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

e in search of a wonder weight loss program, which is easy and quick, which works painlessly, which is safe without side effects, which does not put you through u

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

pleasant and strenuous physical activity, which does not deprive you of your favorite dishes and so on, but negative calorie foods do not meet all your conditions

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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