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This survey has been conducted on the basis of past 10 years which confirms the high prev

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

alence rate of victimization and violence among adolescents considering the number of lar

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

e adolescent and general population studies. Department of Justice in U.S (2002) reported

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

that the violent crime rate for adolescents of 16 to 19 years of age was double of the ra

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

e of individuals of age group 25 to 34.

In order to develop the instrumental form of edu

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ational system promoting the intervening strategy, the relevant methodologies addressing

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

he individual needs for counselling and education for the adolescents suffered from victi

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ization need to be developed. One of the most essential ingredients incorporating the res

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

arch includes concept mapping in order to promote the development and enhancement of mult

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ple types of learning and thinking. It is effective by means of aiding summarization of i

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

eas along with taking important notes and then translation of those documents into reflec

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

tive thinking. The other essential ingredient of concept mapping comprises the idea of br

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

instorming support in which an individual is directed towards a proper direction with an

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

bility to generate newer ideas by means of developing new format of concept mapping.

Acc

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

rding to the prospective, longitudinal survey conducted by National Youth Survey (NYS), t

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

e samples taken are as follows: Americans of age group 11 years to 17 years at the year 1

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

76 (the first collected data), and the same sample of age group 27 years to 33 years at t

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

e year 1992 (the last collected data).

The survey has been conducted into nine waves or

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

nterview cycles, among which the waves numbered from 1 to 5 had been collected annually d

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ring 1976-1980. Since 1980, the survey has been conducted with an interval of three years

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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