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Did you know that high blood pressure is the most common health problem that affects adults in the US. Over 65,000,000 people in the United St

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ates have high blood pressure and 69% of people who have their first heart attack suffer from high blood pressure. The terrifying thing is mo

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

st people don't even know they have it.

A brief overview of blood pressure. Everyone has it but in some cases it can be a health risk, i.e. w

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

hen it is too high or in some cases when pressure is too low. It is the force that is exerted on blood vessels and heart by the flowing of the

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

blood. There are 2 components. One is systolic pressure which is the max pressure in your arteries when your heart is pumping blood around y

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

our body. Two is diastolic pressure, which is the minimum pressure when your heart is resting between beats. In an adult you can expect the n

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ormal blood pressure to be 120 over 80 millimeters of mercury. Anything above these numbers is considered high.

So why is high blood pressure

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

dangerous? People with high blood pressure are more succeptable to heart diseases, heart failure and stroke. Now you don't have to be having

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

these problems to have high blood pressure, other symptoms can include obesity, quick temper and breathlessness, to name a few. It's no wonde

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

r that it's known as the silent killer, most of the symptoms are passed off as general ailments. People don't discover they have it until it'

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

advanced and at a much later stage. As you get older and the less active your lifestyle, the more at risk you will be at developing high blo

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

od pressure. Studies have shown that unhealthy lifestyles feature prominently in sufferers of high blood pressure.

Fear not as preventing an

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

d gaining control of your blood pressure can be relatively simple. Here are some tips -

1 - First things first, check with your doctor to see

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

if you even have high blood pressure. Your doctor will also be able to advice you on what to do.

2 - If you're obese you need to consider a w

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

eight loss program.

3 - Reducing your salt intake will have big impact on your blood pressure. There's so much salt already in prepacked food

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

that adding some extra is a big no no.

4 - You need to moderate your drinking of alcohol.

5 - Smoking is another no no. It's bad for you for

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

so many reasons but it is another cause of high blood pressure and needs to reduced or better yet stopped all together.

You can also take some

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

drugs in addition to the above recommendations to keep your blood pressure under control. Only take prescribed drugs. Although it is recommen

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ded to try to alter your lifestyle before trying the drug route as lifestyle changes can have a huge impact on your blood pressure. Failing

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

to control your blood pressure can lead to other problems and fatal complications. Take action now as prevention is always better than cure

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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