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For many men, hair loss can happen at any time. If this is happening to you, you are not alone.

For many men, losing hair is so

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

mething will have to be faced as part of the aging process. If this is happening to you, you are not alone, as a simple walk down th

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

e street will show you. About 25 per cent of men begin losing hair before they reach 30 and two thirds before the age of 60. Somet

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

imes men can begin losing hair in their teens and can reach their early twenties with very little, if any, hair left on the crown of

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

their head. Usually, however, the hair loss is gradual, developing over a period of twenty to thirty years.

The most common cause

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

of hair loss in men is genetic:

Androgenetic alopecia (male pattern baldness) has a characteristic pattern of hair loss; it begins

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

with a slight recession at the front hairline and is followed by thinning on the crown of the head. The hair above the ears and at

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

the nape of the neck is unaffected. This hair loss results from a complex chemical reaction when the enzyme 5alpha-reductase converts

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

the testosterone in the system into DHT or dihydrotestosterone. The hair follicles are genetically predisposed to be oversensitive

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

to the DHT and become smaller and smaller with time, leading to the eventual hair loss.

If you are suffering from patchy hair loss

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

you may be suffering from another form of alopecia:

Alopecia areata is an extremely common condition and will affect 1% to 2% of t

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

he population at some point in their lives. Most sufferers are children and young adults (below 40 years old), though it can affect

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

people of all ages. The hair loss is sudden and manifests itself in small, smooth- skinned patches that are likely to gradually widen

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

with time. It can also affect the sufferer’s nails, giving them a pitted, ridged or brittle appearance. The exact cause is still un

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

nown, although current theories include an auto-immune disease, stress or suggest a genetic basis. If the hair loss progresses unt

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

il all the scalp hair is lost this is known as alopecia totalis or alopecia universalis if all the body hair is lost as well.

Hair

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

loss can also result from a scalp problem. Inflammation of the scalp leads to production of superoxide, which causes hair shedding a

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

nd will lead to diffuse hair loss.

These are just a few of the reasons for hair loss. It order to treat hair loss effectively we wo

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

uld recommend that you have a diagnosis made as soon as possible by one of our experienced trichologists. Stress can be an aggrava

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

tor in almost all cases of hair loss and an accurate diagnosis will always, at the very least, take some of the stress away from you

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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