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The heart is one of the five major organs of the body, the other being the brain, the liver, the lungs and the digestive system-any defect in or malfunctioning of which leads to serious complications. The major function of the heart is to pump the blood into the arteries and send the blood returning from the various organs with carbon dioxide to the lungs for purificati

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

on.

Considering the amount of work that the heart does-it never stops till death-it is subject to few disorders. The main causes of heart disease are the diseases of the coronary arteries (which nourish the heart muscle), high blood pressure and syphilis. Acute rheumatism-a predominantly infantile disorder-is responsible for most cases of heart disease occurring betwee

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

n the ages of 5 to 45 years. Other causes of heart diseases are disorders like diphtheria, diseases of the thyroid gland and certain forms of chronic lung ailments. A small, but important group of heart diseases is due to the congenital abnormalities of the heart. In those disorders for example, the malformation of the valves or cavities in the valve developed in the mo

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

her’s womb, the only recourse is to heart surgery. Certain deficiency diseases like gross lack of vitamin B cause the condition known as beri-beri.

The tendency of the heart to adjust to changes in the mode of living of its owner, known as compensation, is one of the vital factors, which prolong life in spite of maladies to which this king of organs is susceptible. Thi

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

s adjustment sometimes enables a person to go through life without suspecting the disease, which invade the heart. It is a common fallacy to suppose that heart disease ends in sudden death. A man with a defective heat may live long, if he is careful. It is only when the heart muscle has become weakened due to some other illness, for example, diabetes, that the end may c

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

me suddenly. Another cause of sudden death by heart failure can be ascribed to the formation of a clot in the blood (thrombosis). Hardening of the arteries may lead to failure of the heart, but in most cases that is a gradual development.

Chief Ailments

The broad categories of heart ailments are:

(i) Those caused by inflammation of the muscle, the oute

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

r covering or the inner covering of the heart;

(ii) Hardening of the arteries and formation of a clot which may result in sudden interruption of the functioning of the heart;

(iii) Weakening of the muscle or degeneration of the organ because of advancing years;

(iv) Involvement of the heart as a corollary to rheumatism or syphilis; and

(v) Functional disorders like

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

techycardia, bradicardia or hypertension and arrhythmia (lack of rhythm in the heart beat) and angina pectoris (pain in the chest, behind the sternum) and a sense of impending death.

As stated earlier, naturopathy is the only recourse in case of all bodily ailments. Heart diseases can be cured safely and in a better manner under this system of medicine. The only except

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

on, it may be stated here, is congenital defects of the heart for which surgical interference is necessary after the “compensation” fails to relieve the condition.

Here we give the treatment that is to be under taken in angina pectoris. The same course of treatment would help other heart ailments too regardless of the technical name given by the doctors. Angina pecto

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ris is characterized by a sharp pain in the chest (behind the sternum), which leaves the victim breathless. There is a sense of impending doom. It is generally caused by the constriction of the main artery that leads into the heart, because of its hardening or deposition of fat in the insides. The pain radiates to the back, the shoulders and the arms, particularly the l

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ft arm. The attack may come on after a hearty meal, a sudden over exertion or intense grief or excitement.

Lest the reader confuse a gastric pain with angina, let us make it clear that the true pain of angina has a tendency to spread to the shoulders and the arms. There is a constriction in the chest and profuse sweating. True angina must be differentiated from false o

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

r pseudo-angina which is of a nervous origin.

Drugs taken to relieve angina only help to make the condition more chronic. Patients taking recourse to traditional methods of treatment would be seen carrying tablets of nitro-glycerine to relieve the pain. The drug may be taken in an emergency but the correct treatment for angina begins when it is aimed at building the ge

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

neral health level of the patient.

When an attack is on, the best thing is to apply hot towels over the heart region. That will relieve the constriction around the chest by dilating (through heat) the clogged artery, which finds it difficult to pass the required amount of blood through it to the heart.

Treatment

The best way to deal with heart disease is to st

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

rt a cleansing diet because the cleaner the blood, the less will be chance of any toxicity building up around the region of the heart. The patient should subsist on a diet of fruit and fresh vegetables. His breakfast should consist of two oranges, an apple and grapes. For lunch he should take salad of lettuce, grated carrots and best root together with some boiled veget

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ables and bread made out of whole meal flour. Fats, particularly saturated ones like ghee, should be banned and only a pat of butter –preferably fresh and not the tinned variety—should be taken.

Salt should be avoided totally or taken in small quantities if the patient prefers a non-vegetarian diet they should eat steamed fish or boiled white meat. Fatty portions of me

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

t, particularly pork, should be avoided. He should never overload his stomach because distention of the organ by flatulence or overloading may depress the diaphragm and the pain of angina may start.

Sufferers from heart disease should fast for a short period according to their bodily strength so that the system is not overtaxed. Ailments like indigestion should not be

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

allowed to arise, as they are likely to tax the heart. A heart patient should eat so sparingly that he should feel hungry all the time. The last meal of the day should be taken at least three hours before retiring.

Gravity douche or enema should be taken recourse to in case of constipation. A short walk in the morning and evening is beneficial. Even traditional doctors

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

have come to realize now that walking is the best exercise for a heart patient. Some of them even recommend jogging. A medical fact which should be stated here is that when you are walking the pressure on the heart is reduced to some extent because the blood going back for purification through the heart to the lungs flow back more easily when you are walking than when

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ou are sitting or lying down. Epsom salt bath should be taken once or twice weekly.

A heart patient must have a strict regimen of living in addition to eating. He must avoid stress, worry and excessive physical strain. If he has been on drugs before turning to naturopathy, they should be gradually withdrawn. A sudden stoppage of drugs is not advised.

The above regimen

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

should be followed in all cases of heart disease regardless of their technical name.

For more information regarding Natural Home Remedies for Heart Diseases, Herbal Remedy visit http://www.natural-homeremedies.com

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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