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Stress is now known as a contributing factor to many major illnesses; including heart diseases, strokes and also, diabetes.

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

Specifically, work related stress is associated to many metabolic syndromes including high cholesterol and triglycerides

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

nd high blood pressure. For diabetes prevention, it is therefore important that you manage your stress levels effectively.

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

Diabetes is fast becoming a common disease. There are now 20.8 million children and adults in the United States, or 7% of

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

the population, with diabetes. About two thirds of the 20.8 million people have been diagnosed. The remaining one third ar

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

still unaware that they have the disease.

A study was recently done that involved over 10,000 men and women in the age gr

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

oup 35-55 years old. The study revealed that the more work related stress that a person had, the more likely he will be di

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

gnosed with metabolic problems, including diabetes. In fact, people who work with chronic stress levels were found to have

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

twice as likely to develop diabetes. Thus, researchers concluded that stress does increase the risk of developing a metabo

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

lic problem and/or diabetes.

If you are still working, you are likely to experience work related stress. Diabetes preventi

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

n is necessary; so you have to learning how to cope with stress at work. These are some important questions to ask yourself

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

How do you manage stress at work? Do you carry work home with you? How to you relieve your work related stress levels?

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

Diabetes prevention can start with implementing these tips for your work:

• Take regular breaks. Move around every half an

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

hour or so.
• Do relaxation and stretching exercises at your desk.
• Replace your caffeinated coffee and soda wi

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

h water.
• Leave the work at work if you can.
• If you have leave entitlement, then take them.
• Avoi

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

d social settings where talk revolves around work.
• Use deep breathing and relaxation techniques to relieve stress

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

Maintaining a positive attitude can help reduce your reaction to stress and thus aid in diabetes prevention. If your

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ob is causing most of your stress, then it is time to do something about it. You can try talking to your superior and thin

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

k of ways to make it less stressful. It is also far better to take on a less stressful position than to be stressed and un

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ealthy. For diabetes prevention, there are definitely ways that you can go about improving the stressful situation at work

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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