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From the official web site of Al Capp productions:

"Sadie Hawkins Day, an American folk event, made its debut in Al Capp's Li'l Abner strip November 15, 19

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

37. Sadie Hawkins was 'the homeliest gal in the hills' who grew tired of waiting for the fellows to come a courtin'. Her father, Hekzebiah Hawkins, a prominent resident of D

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ogpatch, was even more worried about Sadie living at home for the rest of his life, so he decreed the first annual Sadie Hawkins Day, a foot race in which the unmarried gals

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

pursued the town's bachelors, with matrimony the consequence. By the late 1930's the event had swept the nation and had a life of its own. Life magazine reported over 200 c

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

olleges holding Sadie Hawkins Day events in 1939, only two years after its inception. It became a woman empowering rite at high schools and college campuses, long before the

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

modern feminist movement gained prominence. The basis of Sadie Hawkins Day is that women and girls take the initiative in inviting the man or boy of their choice out on a da

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

te, typically to a dance attended by other bachelors and their aggressive dates. When Al Capp created the event, it was not his intention to have the event occur annually on

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

a specific date because it inhibited his freewheeling plotting. However, due to its enormous popularity and the numerous fan letters Capp received, the event became an annu

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

al event in the strip during the month of November, lasting four decades."

Now here are my 5 Tips For Women Doing the Asking

1. Walk by faith not by sight. - Confidence i

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

s attractive. Don't underestimate what who you can attract and persuade when you exude confidence. You get what you expect. Don't be over awed by anyone's appearance.

2.

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

Be sincere, stay centered and remain detached. - Ask your guy out with sincerity showing him you are interested, but don't be so enamored with him that your world collapses

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

if he says no. Remember there are 3 billion men on the planet and many will say yes when others say no. Keep fishing and move on when necessary! Yet don't sabotage your s

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

uccess of possibly getting a yes by having an inner tendency to expect rejection. Be sincere. Stay centered and strong within, remaining detached from the object of your d

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

elight.

3. Break the mold and be different. - Have a game plan to differentiate yourself from the rest of the ladies. Dress, walk, talk and carry yourself differently. H

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ave a plan as to where you'd like to go, what you'd like to do wherewith you can interest him beyond you. Generate a multiplicity of interests to prompt curiosity and mutua

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

desire.

4. Position yourself conveniently for interaction. - Find out what he likes, where he goes and with whom he associates. Conveniently show up at the right place at

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

the right time when endeavoring to ask him out. The more you show yourself seemingly to be engaged in his interests, involved in his friendships and in his social circle t

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

he easier it shall be to persuade him favorably to say yes.

5. If butterflies have got the best of you, write him a note expressing your desire and inviting him out. - No

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

t only is a letter easier for you to transfer your feelings by, it minimizes any pain should a less than favorable reply come back. When we seemingly are unable to communic

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ate when nervous, taking time to put your thoughts on paper can be both therapeutic and present yourself in the best possible way.

Happy hunting on Sadie Hawkins Day ladies

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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