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Ryan Phillippe and Reese Witherspoon have separated, and the media clamors to know whether the split is due to the fact tha

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

t Ryan's considerable success has been overshadowed by his wife's. You may remember that Reese Witherspoon won the Oscar fo

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

Best Actress in 2005 for her performance in Walk the Line.

The Successful Wife Equals Marital Doom theory just won

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

t die. The Connecticut Post ran a story (first published in the Sacramento Bee) about it recently. Meredith V

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

era and Matt Lauer discussed it on Today, and so did the women on The View.

It's another form of the "a girl

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

should always let the boy win" rule that our less-enlightened mothers taught us when we were children. The idea is that if

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ou out-earn (or outshine) a man, he will dump you (or cheat on you, or just make your life generally miserable).

But hidin

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

your light under a bushel to make a man feel good about himself is dangerous for two reasons: You'll never reach your own

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

otential. And you will likely attract men who need to control you to feel good about themselves.

While that may seem like

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

small thing when your romance is new and exciting, trust me, after a mortgage and a couple of kids, it could kill you. A v

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ry good friend of mine is married to a man who is threatened by her smallest successes (a longtime stay-at-home mother, she

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

recently attempted to start a homebased business). Her husband's response was to tell her that "nobody will want that ____

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

_." On occasion, he has hit her.

As a result, she's depressed and drinks too much (this is a woman who, as a girl, scored

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

s "brilliant" on standardized tests). Instead of getting her into AA or rehab, he brings home cases of beer. She's easy to

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

control when she's been drinking. (In case you're wondering what kind of man I'm talking about, he's a VP with a major corp

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ration.)

I don't know Reese Witherspoon or Ryan Phillippe, and I do hope the media have it wrong about the cause of the de

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ise of their relationship. I hope their difficulties have nothing to do with her success, and that they can overcome them.

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

As for me, I'd rather be alone than spend my life with a man who didn't want what's best for me and who let his insecuritie

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

get in the way of my well-being. I hope you will not ever diminish yourself in your efforts to attract a man. The men who

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

eserve you want you as you are. They will encourage your success. In fact, they'll rejoice in it.

You deserve nothing less

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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