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    As a consequence of modern life and modern industrial economy, every year the proportion of people staying in cities increases as compared to those sta
    According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
    ying in villages. Of the many facets of city life is one where one may live in a city home or apartment for years without having any social interaction
    ; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

    Examples of combination products may in
    with one’s immediate neighbors.

    One commemorates or celebrates special events such as deaths, anniversaries, birthdays and weddings in city homes just
    lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

    as much as village people do in village homes, and it may sometime happen that one invites friends and relatives to such an occasion from different par
    here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
    s of the city but not one’s neighbors. There is an old saying to the effect that if an event is celebrated where no friends or relatives are invited th
    d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

    Combination pro
    n the gods may still bless it if they deem fit, but if an occasion is celebrated without inviting any neighbor the gods too shall withhold their blessi
    ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
    g. One may not believe in God or gods in the modern scientific world but it would be unwise to reject the wisdom hidden in old proverbs and sayings.

    A
    easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
    n excellent practice some city neighborhoods have started is to define a group of twelve neighboring homes and then fix the last Sunday evening of a mo
    nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
    th for a neighborhood get-together. If a particular homeowner is busy in the month when his or her turn comes he can exchange his assigned month with a
    and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
    other neighbor by mutual arrangement. Such get together's are good occasions to discuss a neighborhood issue and thereby improve the neighborhood. They
    ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
    also serve as a forum to exchange any useful information about the neighborhood such as the availability of a new opportunity, service or potential haz
    ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

    Following aspects would a
    rd that you may not have heard about.

    Even if one does not wish to be friendly with one’s neighbors there may be an occasion when one has to deal with
    dd to the challenges in developing combination products:

    Which markets to tap where the combination products can do fairly well?
    Which combination prod
    them for a neighborhood issue, or seek their help in an emergency therefore it is definitely not wise to ignore neighbors totally. Moreover, neighbors
    cts are meaningful and rational?
    Which therapeutic categories to select?
    Which Combinations can address unmet needs of the patients?
    Do combin
    ave you on their mind more frequently than relatives. Perhaps telepathic bad wishes of neighbors are not effective but they can remain silent when they
    tions increase the patient compliance?
    What would be the developing cost?
    How to tackle the risks encountered during combination product developmen
    see a break-in taking place into your place perhaps even gloat at it incase you have been particularly mean. Moreover no one can stop a neighbor from
    t?

    As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
    bserving and gossiping to other neighbors if they wish to. It is true that some neighbors are interfering if one becomes friendly or they may not be yo
    ping new procedures for reviewing their safety, efficacy and quality.

    Professional from academic institutions, pharmaceutical industries, health care indust
    r type or perhaps they are too aloof to have bothered to talk to you. This is when a special occasion comes in handy. Inviting them on a special occasi
    y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
    n provides an excuse to invite them and does not translate into daily friendships. Probably there are enough people present at a celebration so that i
    .

    As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
    does not matter if some are not your type. So next time there is an occasion at your place worth inviting people you need not become a good Christian
    elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

    Companies that provide selfless information through particip
    uddenly by loving your neighbor, but don’t forget them, and may the best wishes of this author be with you for that occasion, provided you have done so


    tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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